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KMID : 1038820170200010041
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Pediatric Gastroenterology, Hepatology & Nutrition
2017 Volume.20 No. 1 p.41 ~ p.46
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Effect of the Baseline Vitamin D Level on Growth Outcome in Pediatric Crohn Disease
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Lee Eun-Joo
Moon Jin-Soo
Ko Jae-Sung
Yang Hye-Ran
Jang Ju-Young
Kim Ju-Whi
Lee Kyung-Jae
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Abstract
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Purpose: Vitamin D deficiency is common in Crohn disease (CD). The aim of the study was to examine the prevalence of vitamin D deficiency and evaluate the association between vitamin D status and growth outcome in Korean pediatric CD patients.
Methods: In this retrospective study, 17 children younger than 18 years old diagnosed with CD were enrolled and their serum 25-hydroxy vitamin D (25[OH]D) was checked between 2011 and 2015. We categorized the patients into two groups, Group 1 and Group 2. Group 1 included patients with serum 25(OH)D levels below 10 ng/mL, and Group 2 was for patients with a 25(OH)D serum levels between 10 ng/mL and 30 ng/mL. The z-scores for height (Htz), weight (Wtz), and body mass index (BMIz) were measured at baseline, 6 months, and 12 months.
Results: The mean serum 25(OH)D levels of the total 65 CD patients and 17 enrolled patients were 15.64±6.9 ng/mL and 13.1±5.1 ng/mL , respectively. There was no correlation at the beginning of the study between vitamin D level and growth parameters (Htz, Wtz, BMIz) or other variables including laboratory data and Pediatric Crohn Disease Activity Index. The Htz, Wtz, and BMIz in Group 1 showed no significant improvement at 6 months and 12 months follow-up. In Group 2, Wtz and BMIz showed significant improvements sustained until 12 months of follow-up. Htz showed no significant improvement at 6 months but there was significant improvement at 12 months.
Conclusion: It seems that baseline vitamin D status affects growth outcome in pediatric CD.
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KEYWORD
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Pediatric Crohn's disease, Vitamin D, Growth
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